I believe mental/physical health is the biggest thing that suffers.If we can maintain good health inspite of the job pressures,then it means we are striking a balance.
Health and friendship are two things whose importance is understood only when they are lost.
Find friends who trust you and who can understand your job pressures and hence are friends in all circumstances.
For some people just an e-mail will do.I think once has to manage time to get enough room for little time to be given to friends