You are correct in saying that lot of answers are hypothetical.
Legally, language of the agreement wise, I do not see any problem except the concerns about Clause 10, I gave my opinionon my gut feeling.
Today KRISHNAKUMAR P wrote a article that explains some of the salient points of this agreement. He explains that this agreement is for civilina nuclear cooperation and thus military aspect does not come into picture, so I assume that India's obligations under NPT & CTBT remain status quo.
I have been advocating that India should not have FEAR of US.
If there are no concerns left, then this is as good a time as any. India should go ahead irrespective of consequences.