as a matter of fact, the bigger an aircraft is, stringer are the security norms for it. If you see the crash history in civil air aviation, you will find the smaller planes with most crashes.
for example boeing 747 has had many crashes whereas boeing 777 has had none.
though I agree with you that A380 wont be able to land on small airports, but for all other factors, it is much safer than a small aircraft.
It's a thumb rule in avaition to prefer bigger aircarafts from the point of view of safety.
