e.g. if we look at he example supporting both side of Mr. Dhirubhai Ambani & Mr. Narayan Murthy, the time frame in which Mr. Dhirubhai created wealth was little longer than time frame in which Mr. Narayana Murthy of Infosys crated wealth. There lies the difference between Degree holders & Experienced (who learned through trial and error method).
The advantage of getting professional degree is person can learn pro and cons of the industry learn from experienced people, industries past success/failure stories etc. So they know well how to deal in which situation. As they get experienced day by day they are becoming unbeatable.
So in this 21st century ultimate combination would be to have qualified degree and getting experienced day by day and moment by moment. Learn from surrounding environments, learn, learn and learn by any means. That is the only success formula in this dog eats dog competition. This is what I feel as per my experience.